Hyperuricemia and Gout

1 which of the following statement are correct about gout
I it is the deposition of monosodium urate—in and around the joints
II it is the recurrent painful acute attacks of urate crystal-induced arthritis
III it is the elevation of serum uric acid level above normal

2 which of the following are true about uric acid
I Uric acid is an end product of purine metabolism
II Xanthine oxidase catalyzes degradation of purines to uric acid
III uric acid is excreated via the kidneys (300–600 mg/day)

3 hyperuricemia is a result of which of the following
I uric acid underproduction
II uric acid overproduction
III impaired renal clearance of uric acid

4 which of the following drugs cause hyperuricemia;
I Diuretics
II Cyclosporine
III spironolactone

5 which of the following is correct about acute gout treatment
I Urate-lowering drugs therapy should begin immediately
II Anti-infl ammatory drug therapy should begin immediately
III Urate-lowering drugs should not be given until the acute attack is controlled

6 which of the following is correct about the use of NSAIDS in acute gout
I Begin with high doses for 2 to 3 days, then taper the dose rapidly over the next several days
II Begin with low doses for 2 to 3 days, then increase the dose rapidly over the next several days
III begin with low dose and maintain the low dose

7 NSAIDs, require cautious use in patients with the following conditions
I hypertension
II congestive heart failure (CHF)
III peptic ulcer disease and mild to moderate renal failure

8 which of the following is correct about colchicine treatment in acute gout
I relieves pain and inflammation
II most effective when started within 24 hrs after symptoms begin
III impairs leukocyte migration to inflamed areas

9 which of the following correct about colchicine
I It has no effect on serum urate levels
II it may cause GI side effect
III it will decrease serum urate level

10 which of the following are the side effect of Chronic colchicine therapy
I neuromyopathy
II hypertension
III kidney failure